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Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other minor skin conditions such as eczema. Brand names include Alphatrex, Beta-Val, Diprolene, Diprolene AF, Diprosone, and Luxiq. Minor side effects include dry skin and mild, temporary stinging when applied.〔("Betamethasone Dipropionate Side Effects" ), ''drugs.com''〕 Betamethasone dipropionate is a "super high potency" corticosteroid used to treat inflammatory skin conditions such as dermatitis, eczema and psoriasis. It is a synthetic analog of the adrenal corticosteroids. Although its exact mechanism of action is not known, it is effective when applied topically to cortico-responsive inflammatory dermatoses.〔http://www.drugs.com/pro/diprolene.html#dosage〕 ==Adverse effects== Although the absorption of betamethasone dipropionate is small, when used for prolonged periods of time (periods exceeding two weeks), or across a large surface area (total use greater than 50 grams per week), it can have adverse affects. One such effect is the ability of the corticosteroid to suppress the hypothalamic–pituitary–adrenal axis.〔〔http://www.rxlist.com/diprolene-ointment-drug/indications-dosage.htm#D〕 This can lead to a depression in the release of adrenal hormones such as cortisol and adrenocorticotropic hormone, or ACTH. Symptoms of HPA axis suppression are often subtle and variable. but can often be detected using simple blood or urine tests such at ACTH stimulation test or urinary free cortisol.〔http://www.rxlist.com/diprolene-ointment-drug.htm〕 Those at increased risk for HPA axis suppression are those who are more likely to absorb more of the steroid through the skin. These groups include: *Those who have used topical corticosteroids over a prolonged period of time *Those who have used corticosteroids to cover a large surface area *Those with broken skin barrier or extensive abrasions *Those who have recently undergone stress (such as illness, trauma, surgery) *Children under the age of 12 HPA axis suppression is preventable but supplementation with glucocorticosteroids. If HPA axis suppression occurs, it is often reversed shortly after discontinuation of treatment.〔http://www.medpagetoday.com/Dermatology/Steroids/777〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Betamethasone dipropionate」の詳細全文を読む スポンサード リンク
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